GHRP-6 5mg
GHRP-6 – early growth hormone-releasing peptide, studied in relation to GH release and appetite signalling. Price and batch analysis.
29.00 EUR · In stock
This product is intended solely for scientific and research use, as well as for use as a reference standard in HPLC analysis, and is not an approved medicinal product. It is not intended for the diagnosis, treatment or prevention of disease in humans or animals. It has not been approved by the FDA, the EMA or any national regulator. The information on this page is provided for scientific information purposes only and does not constitute medical advice, a recommendation for use, or any claim of clinical efficacy or safety.
GHRP-6 – what is the peptide
GHRP-6 is a synthetic hexapeptide and one of the first described representatives of growth hormone-releasing peptides. It acts on the ghrelin receptor and has historical significance for the identification of this receptor system.
The compound is characterized by its pronounced appetite-stimulating component – a property that distinguishes it from the later, more selective analogues in the group.
It is precisely through research with GHRP-6 and its related molecules that the existence of a receptor distinct from that of GHRH was established, which subsequently led to the discovery of ghrelin.
Mechanism of Action
Binding to the ghrelin receptor in the pituitary gland triggers the release of growth hormone via a pathway independent of the GHRH receptor. The two pathways act synergistically when activated simultaneously.
Binding to receptors in the hypothalamus is involved in the regulation of appetite. In GHRP-6, this component is the most pronounced among the compounds in the group and is noticeable even at low concentrations.
Effects on cortisol and prolactin are also described, which distinguishes the compound from selective analogues such as Ipamorelin.
Research Data and Observations
Observations track growth hormone concentrations following administration, while simultaneously recording changes in cortisol, prolactin, and feeding behavior.
A separate line of research examines the appetite effect itself, independent of the secretagogue activity, as it is of independent interest.
A decrease in response is noted with prolonged administration.
When interpreting published data, the difference between preclinical and clinical conditions should be taken into account. Results from cell cultures and animal models describe a mechanism but do not allow quantitative conclusions for human conditions.
The dose ranges used in preclinical studies are often not directly translatable due to differences in metabolism between species. This limitation is consistently noted in review papers.
Example Calculations
The calculations below are purely mathematical examples showing the relationship between the total amount of substance, the volume of solvent, and the resulting concentration. They do not constitute a recommendation for dosing, administration schedule, or instructions for use.
When reconstituting 5 mg with 2 ml of bacteriostatic water:
The resulting concentration is 2.5 mg/ml, with 0.40 ml containing 1 mg of substance.
Example values:
- 0.1 ml = 0.25 mg
- 0.2 ml = 0.5 mg
- 0.3 ml = 0.75 mg
- 0.4 ml = 1 mg
- 0.5 ml = 1.25 mg
Overview of Scientific Publications
GHRP-6 is among the longest-studied compounds in the group, and the literature on it spans over three decades, including works of historical significance for the field.
Older publications use methodologies that are not always directly comparable to modern ones.
Safety data from studies
The most characteristic observation described is a pronounced feeling of hunger, occurring shortly after administration. Increases in cortisol and prolactin, as well as reactions at the injection site, are also reported.
The response decreases with prolonged administration.
A general limitation of compounds in this category is the absence of long-term controlled studies in humans. Available information describes mechanism and short-term observations, not a safety profile for prolonged use.
This product is intended exclusively for research purposes. It is not a food, dietary supplement, or medicinal product and is not intended for the diagnosis, treatment, or prevention of any disease.