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Peptides Tested at Janoshik Labs
PT-141, also known as Bremelanotide, is a synthetic peptide from the melanocortin agonist group, developed as an analogue of α-MSH (α-Melanocyte-Stimulating Hormone). In studies, activation of the melanocortin receptors MC3R and MC4R has been observed in the central nervous system, which is associated with the regulation of sexual function, energy balance, and neuroendocrine response.
PT-141 differs from Melanotan II in that it primarily targets central neuroregulation rather than peripheral effects such as melanogenesis. In research settings, it has been used as a model to study the neuromodulation of sexual behavior, vasodilation, and the hypothalamic-pituitary axis, as well as for its potential connection to libido and mood.
In scientific literature, PT-141 has been studied in relation to:
Regulation of sexual function - activation of MC4R in the central nervous system
Neuromodulation of libido - influence on dopamine and endorphin pathways
Effect on vasodilation and blood flow in the sexual organs
Regulation of energy balance and appetite
Studies of the melanocortin system and its interaction with other neurotransmitters
Potential role in adaptation to stress and central fatigue
PT-141 has been studied in preclinical and limited clinical models for its effects on sexual responsiveness and neurochemical mechanisms:
Activates MC3R and MC4R receptors, leading to stimulation of neuronal pathways associated with libido
In living models, it has shown improved sexual motivation and frequency of copulatory behaviors
In human studies, increased sexual interest and arousal have been observed
Does not directly affect the cardiovascular system or the hormonal levels of GH and IGF-1
Is being studied as a potential neuromodulator of the hypothalamic-pituitary axis
In scientific literature, PT-141 doses between 500 and 2000 μg are typically cited, administered subcutaneously, depending on the research model. Due to its central action, effects occur relatively quickly – within 30 to 120 minutes. Studies use both single applications and short series.
With 10 mg + 3 ml bacteriostatic water:
Concentration = 3.3 mg/ml → 0.15 ml = 500 μg
Example values:
0.15 ml = 500 μg
0.30 ml = 1 mg
0.45 ml = 1.5 mg
0.60 ml = 2 mg
In research settings, PT-141 is considered well-tolerated. In published studies, mild and transient reactions have been reported, including:
slight nausea or dizziness
transient increase in blood pressure
facial flushing or feeling of warmth
changes in sexual motivation in experimental models
fatigue or slight drowsiness after application
Most reactions are described as transient, dose-dependent, and resolving within a few hours. No serious adverse effects have been reported at research concentrations.
The information is based on scientific publications and is purely educational. It is not intended for the diagnosis, treatment, or prevention of diseases.