What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide of the GHRP (Growth Hormone Releasing Peptides) family that acts as a selective agonist of the ghrelin receptor (GHS-R1a). It stimulates the pituitary gland to secrete growth hormone (GH), but unlike other GHRP peptides, it shows a more selective profile and a lower likelihood of increasing cortisol and prolactin. In research settings, Ipamorelin has been described as one of the most balanced and well-tolerated GHRP peptides. In research settings, it is being studied for its effects on muscle growth, tissue regeneration, bone health, and metabolism.
Observations on Ipamorelin
Ipamorelin is being studied for its possible effects on:
Growth hormone stimulation - enhances GH pulses without a pronounced increase in prolactin and cortisol.
Increase muscle mass - supports protein synthesis and anabolic processes.
Improved recovery - accelerates regeneration after exercise.
Joint and bone health - stimulates mineralization and tendon repair.
Improved sleep quality - supports deep sleep phases.
Anti-aging effects - enhances IGF-1 secretion and supports cell regeneration.
Fat reduction - stimulates lipolysis and improves metabolic balance.
Cardioprotective effects - experimentally shows a protective effect on cardiac function.
Scientific data
Ipamorelin has been studied in preclinical and limited clinical studies.
In endocrinology, it has shown reliable GH stimulation without significant changes in ACTH, cortisol, and prolactin levels.
In orthopedics and sports medicine, it is being studied for its effects on muscle, tendon, and bone regeneration.
In gerontology, interest is focused on its potential to slow age-related changes associated with loss of muscle mass and bone density.
In cardiology and neurology, it is being studied as a possible protective agent against cellular damage and oxidative stress.
Dosage and administration
The scientific literature describes subcutaneous administration of 200-300 μg daily, divided into 1-3 applications.
At 10 mg + 3 ml bacteriostatic water:
Concentration = 3.3 mg/ml → 0.06 ml = 200 μg
Example values for 10 mg:
0.06 ml = 200 μg
0.12 ml = 400 μg
0.18 ml = 600 μg
0.24 ml = 800 μg
Application in sports
Ipamorelin is banned by WADA for use in professional sports because it can:
Possible side effects
Ipamorelin is generally considered well tolerated. Reported reactions are rare and mild:
At higher doses, rare cases of dizziness or temporary changes in appetite have been observed.
The information has been collected and systematized from various scientific sources and studies. It serves educational purposes only and should not be used for the diagnosis, treatment or prevention of diseases .