Source: Sosne G. et al., Frontiers in Pharmacology, 2022, 10.3389/fphar.2022.928133
To evaluate the effect of Thymosin Beta-4 (TB-500) on tissue healing, inflammation, and cell migration in models of injury and inflammatory diseases.
TB-500 is a synthetic form of thymosin β4 — a peptide naturally found in cells that participates in repair processes, angiogenesis, cell migration, and anti-inflammatory protection. The study aims to determine whether administration of TB-500 can accelerate recovery and reduce the inflammatory response.
Type: preclinical, experimental study
Models: animal models (mice and rabbits) with induced wounds and inflammation
Administration: topical (gel, drops) and systemic (injection)
Doses: 0.5 – 5 mg/kg depending on the model
Duration: 7–21 days depending on the protocol
Measured parameters:
Rate of wound healing
Angiogenesis and cell migration
Inflammatory cytokine levels
Histological tissue analysis
Regeneration and Healing
TB-500 significantly accelerates wound closure (up to 2× faster compared to control).
Stimulates angiogenesis and formation of new capillaries around the damaged area.
Increases expression of VEGF and actin-binding proteins that support cell movement.
Anti-inflammatory Effect
TB-500 reduces levels of TNF-α, IL-1β, and IL-6 in affected tissues.
Reduces infiltration of inflammatory cells (neutrophils, macrophages).
Cell Migration and Recovery
Increases mobility of fibroblasts and keratinocytes.
Improves organization of the extracellular matrix and collagen fibers.
Safety
No toxic effects or behavioral changes were observed in the animals.
Good local tolerability with both topical and systemic administration.
TB-500 accelerates recovery and reduces inflammation in various injury models.
Stimulates cell migration and angiogenesis, supporting regeneration.
Shows an excellent safety and biological activity profile.
Suitable for research into muscle, tendon, and skin injuries.
Preclinical models – lack of clinical data in humans.
No optimal dose has been established for systemic administration.
Long-term effects in chronic injuries have not been monitored.
TB-500 is a promising peptide for regenerative medicine.
Suitable for research into muscle and tendon injuries, wounds, and inflammatory processes.
Clinical trials are needed to confirm effects in humans.