{"product_id":"aaigf-lr3","title":"IGF-1 LR3 (Long arginine 3) 1mg","description":"\u003ch1\u003eWhat is IGF-1 LR3?\u003c\/h1\u003e\n\u003cp class=\"p1\"\u003eIGF-1 LR3 (Insulin-Like Growth Factor-1 Long Arg3) is a synthetically modified form of human Insulin-like Growth Factor 1. The molecule contains 83 amino acids and differs from endogenous IGF-1 by replacing the third amino acid position with arginine (Arg3), as well as by an added 13-amino acid sequence in the N-terminal region. These structural changes are associated with a longer biological half-life and lower affinity for IGF-binding proteins. In scientific literature, IGF-1 LR3 has been primarily considered in the context of cell growth, differentiation, and the regulation of protein metabolism.\u003c\/p\u003e\n\n\u003cp class=\"p1\"\u003eAs a stabilized analogue of IGF-1, IGF-1 LR3 has been used in various experimental models to study its interaction with IGF-1 receptors and the activation of intracellular signaling pathways such as PI3K\/Akt and MAPK\/ERK. These mechanisms are linked to processes like protein synthesis, cell proliferation, tissue regeneration, and metabolic regulation. Due to its extended half-life, described in the range of approximately 20–30 hours, IGF-1 LR3 is often used as a model compound in studies on longer-lasting anabolic and cellular processes.\u003c\/p\u003e\n\n\u003ch1\u003e\u003c!-- Изображение --\u003e\u003c\/h1\u003e\n\u003cp class=\"p1\"\u003e\u003cbr\u003e\u003c\/p\u003e\n\n\u003ch2\u003eObservations for IGF-1 LR3\u003c\/h2\u003e\n\u003cp class=\"p1\"\u003eIn published scientific and preclinical data, IGF-1 LR3 has been considered in connection with the following:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cp class=\"p1\"\u003eCell growth and differentiation – involvement in mitogenic and anabolic processes\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp class=\"p1\"\u003eProtein synthesis – activation of signaling pathways related to hypertrophic mechanisms\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp class=\"p1\"\u003eTissue regeneration – experimental models related to muscles, tendons, and nervous tissue\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp class=\"p1\"\u003eInsulin-like activity – influence on glucose and amino acid transport to cells\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp class=\"p1\"\u003eStudies on metabolic regulation and glucose homeostasis\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp class=\"p1\"\u003eNeuroprotective mechanisms – potential role in maintaining neuronal structure and survival\u003c\/p\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e \u003c\/p\u003e\n\n\u003ch2\u003eAdministration and Dosage\u003c\/h2\u003e\n\u003cp\u003eIn scientific literature, experimental quantities in the range of 20–100 μg daily are found, used in controlled research settings. IGF-1 LR3 is primarily considered in short-term experimental models aimed at evaluating cellular proliferation, anabolic activity, and receptor-mediated signaling.\u003c\/p\u003e\n\n\u003cp\u003eFor 1 mg + 3 ml bacteriostatic water:\u003c\/p\u003e\n\u003cp\u003eConcentration = 0.33 mg\/ml → 0.06 ml = 20 μg\u003c\/p\u003e\n\u003cp\u003eApproximate values:\u003c\/p\u003e\n\u003cp\u003e0.06 ml = 20 μg\u003c\/p\u003e\n\u003cp\u003e0.15 ml = 50 μg\u003c\/p\u003e\n\u003cp\u003e0.3 ml = 100 μg\u003c\/p\u003e\n\n\u003cp\u003eFor 2 mg + 3 ml bacteriostatic water:\u003c\/p\u003e\n\u003cp\u003eConcentration = 0.66 mg\/ml → 0.06 ml = 40 μg\u003c\/p\u003e\n\u003cp\u003eApproximate values:\u003c\/p\u003e\n\u003cp\u003e0.06 ml = 40 μg\u003c\/p\u003e\n\u003cp\u003e0.15 ml = 100 μg\u003c\/p\u003e\n\u003cp\u003e0.3 ml = 200 μg\u003c\/p\u003e\n\n\u003cp\u003e \u003c\/p\u003e\n\n\u003ch2\u003eScientific Data\u003c\/h2\u003e\n\u003cp class=\"p1\"\u003eIGF-1 LR3 has been the subject of preclinical and limited experimental research as a long-acting analog targeting the IGF-1 receptor system.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cp class=\"p1\"\u003eIn cellular models, activation of the PI3K\/Akt signaling pathway and increased protein synthesis in myocytes have been described\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp class=\"p1\"\u003eIn experimental conditions, stimulation of hypertrophic processes and reduction of proteolysis have been observed\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp class=\"p1\"\u003eIn neuronal cultures, IGF-1 LR3 is associated with improved cell survival\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp class=\"p1\"\u003eIn tissue models related to injury and recovery, its potential to accelerate regenerative processes has been studied\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp class=\"p1\"\u003eIts mechanism is not related to an increase in GH, but to direct interaction with IGF-1 receptors\u003c\/p\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e \u003c\/p\u003e\n\n\u003ch2\u003eApplication in Sports and Research Settings\u003c\/h2\u003e\n\u003cp class=\"p1\"\u003eIGF-1 LR3 is included in the WADA list as a prohibited substance due to its potential anabolic effect. In laboratory and academic settings, the compound is used as a tool to study cell growth, protein metabolism, and signaling cascades related to IGF-1 receptor activity.\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cp class=\"p1\"\u003eA model for studying anabolic mechanisms without directly increasing GH\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp class=\"p1\"\u003eStudies on muscle regeneration and recovery processes after tissue damage\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp class=\"p1\"\u003eResearch on metabolic regulation, insulin signaling, and nutrient substrate transport\u003c\/p\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\n\u003ch2\u003ePossible Side Effects\u003c\/h2\u003e\n\u003cp class=\"p1\"\u003eIn the available scientific literature, IGF-1 LR3 is generally described as well-tolerated within experimental conditions. Transient and dose-dependent reactions have been noted:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\u003cp class=\"p1\"\u003eLocal redness or discomfort at the site of experimental application\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp class=\"p1\"\u003eMild fatigue or drowsiness\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp class=\"p1\"\u003eHeadache or feelings of weakness at higher experimental quantities\u003c\/p\u003e\u003c\/li\u003e\n\u003cli\u003e\u003cp class=\"p1\"\u003eReduction in blood sugar in sensitive models or individuals\u003c\/p\u003e\u003c\/li\u003e\n\u003c\/ul\u003e\n\n\u003cp class=\"p1\"\u003eThe described reactions are predominantly transient and depend on the quantity and study conditions. No severe adverse reactions have been reported in published data for controlled research applications.\u003c\/p\u003e\n\n\u003cp class=\"p1\"\u003e\u003cem\u003eThe information is based on scientific literature and is for educational purposes. It does not constitute medical advice and is not intended for diagnosis, treatment, prevention, or use in humans or animals.\u003c\/em\u003e\u003c\/p\u003e","brand":"My Store","offers":[{"title":"1mg","offer_id":53386105848151,"sku":"PP-IGF-1-LR3-5MG","price":99.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1011\/8902\/6135\/files\/1-2_2f7ea207-3d0e-4104-8739-63a173bc50bc.png?v=1779544789","url":"https:\/\/purepeptide.eu\/products\/aaigf-lr3","provider":"PurePeptide","version":"1.0","type":"link"}